3B). R526 from your loop amongst ?J and ?I anchors the C-terminal portion of the activation loop by forming a salt bridge with E458 at The bottom of ?EF. Q459 stabilizes the HRD motif by a hydrogen bond to the key chain carbonyl of R413. The tip of the activation segment is stabilized by a hydrogen bond concerning Y454 and E480 from ?F. inside the … Read More

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